For decades, the scientific understanding of how the human brain regulates appetite has been almost exclusively focused on the activity…
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Tanycyte-derived lactate activates astrocytic HCAR1 to modulate glutamatergic signaling and POMC neuron excitability
A decade-long international collaboration has culminated in a breakthrough discovery that fundamentally alters the scientific understanding of how the human…
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Brain-Based Signaling Pathway Identified as Key Mechanism for Metformin in Controlling Blood Glucose Levels
For more than six decades, metformin has served as the foundational pharmacotherapy for the management of type 2 diabetes, helping…
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MIT Researchers Uncover How Exercise Directly Stimulates Nerve Growth Through Biochemical and Physical Signaling
In a landmark study that redefines our understanding of the relationship between the muscular and nervous systems, engineers at the…
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Breakthrough Research Reveals the Brain as a Primary Driver of Metformin’s Anti-Diabetic Effects through Rap1 Signaling
For more than six decades, metformin has served as the foundational pharmacotherapy for the management of type 2 diabetes, a…
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UCSF Researchers Uncover Biological Circuit Linking Gut Immune Response to Brain Signaling and Appetite Suppression During Parasitic Infection
The phenomenon is a familiar one: the sudden and profound loss of appetite that accompanies a severe gastrointestinal illness. While…
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Mechanical Forces and Tissue Stiffness Identified as Primary Regulators of Chemical Signaling in the Developing Brain
The intricate process of brain development relies on the precise navigation of neurons as they extend axons—long, slender projections—to connect…
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Eli Lilly’s Triple Agonist Achieves 16.8% Weight Loss in Phase 3 Trial for Type 2 Diabetes, Signaling Major Therapeutic Advance
Eli Lilly and Company today announced groundbreaking results from a Phase 3 clinical trial for its investigational triple agonist, retatrutide,…
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